Determination of Ranitidine Hydrochloride in Pharmaceutical Preparations by Direct Potentiometriy

A direct potentiometric titration method was applied for determination of Ranitidine Hydrochloride. The method is based on the treatment of the primary data with nonlinear regression procedure using commercial software. A general formula valid for every type of acid base titration, derived before is used as a direct input. The acid-base constants of N, N dimethyl-5 [2-(1-methylamine-2-nitrovinyl) ethylthiomethyl] furfurylamine hydrochloride were determined by this method in aqueous solutions (I=0.2 mol/l KCl) at t= 25oC. The obtained pK-values were further used for development of potentiometric method for determination of Ranitidine Hydrochloride in tablets. The validation of the method showed very good accuracy and precision. The present approach can be successfully used in routine analysis of the drug in quality control laboratories.